久久综合九色综合欧洲色-久久综合九色综合桃花-久久综合九色综合网站-久久综合久久综合九色-亚洲影院在线播放-亚洲永久视频

技術文章您現在的位置:首頁 > 技術文章 > BroadPharm-什么是陽離子脂質?

BroadPharm-什么是陽離子脂質?

更新時間:2022-08-24   點擊次數:1472次

What are Cationic Lipids?

Cationic lipids are a class of lipid molecules with a permanent positive charged head group with structure as exemplified by molecule DOTAP (Figure 1). Because of the structure specialty, Cationic lipid are an amphiphilic entity with a head group having hydrophilicity and lipid tails possessing hydrophobicity.


Figure 1: Structure of DOTAP


Application of Cationic Lipid

The first publication about Cationic lipids to transfect DNA into cells was published by Philip Felgner. Currently, Cationic lipids have become one of few major class of molecules in lipid nanoparticle (LNP) drug delivery vehicles, mRNA vaccine encapsulation. Cationic lipids neutralize negative charges and facilitate encapsulation and cell uptake in lipid nanoparticles (LNP). Usually unsaturated, short (<30 monomer) hydrocarbon chains of the lipids are associated with the highest transduction efficiencies. In aqueous environments, these lipids form micelles with positively charged surfaces that complex with DNA. These lipoplexes act to neutralize charge repulsion between the cell membrane and DNA and promote endocytosis, similar to the mechanism of cationic polymers.

Lipid supplier and customer synthesis

As a leading biochemical supplier worldwide, BroadPharm offer a wide array of Lipid molecules, such as Ionizable lipids, cationic lipids, helper lipids, and PEG lipids to our clients worldwide. BroadPharm also provides fast speed custom synthesis of novel lipid molecules to empower your advanced research.


參考文獻Journal Reference:

1. S. Simoes, A. Filipe, (March 2, 2005). "Cationic liposomes for gene delivery". Expert Opinion on Drug Delivery. 2 (2): 237-254.

2. X. Hou, T. Zaks, R. Langer, Y. Dong, "Nature Review Materials", (2021)

3.B. Pitard, D. Habrant , Supramolecular Medicinal Chemistry and Chemical Biology, in Comprehensive Supramolecular Chemistry II, 2017


靶點科技(北京)有限公司

靶點科技(北京)有限公司

地址:中關村生命科學園北清創意園2-4樓2層

© 2025 版權所有:靶點科技(北京)有限公司  備案號:京ICP備18027329號-2  總訪問量:321795  站點地圖  技術支持:化工儀器網  管理登陸

主站蜘蛛池模板: 亚洲欧美一级夜夜爽w | 91成人免费福利网站在线 | 欧美抠逼视频 | 赘婿动画在线观看免费完整版 | 亚洲欧洲精品在线 | 四虎影永久在线高清免费 | 国产99视频精品免费观看7 | 亚洲综合校园春色 | 久久青青视频 | 日韩中文字幕精品 | 日本成人免费在线 | 国产视频二 | 国产精品三级 | 草逼视频下载 | 韩国一级毛片完整高清 | 四虎影视免费在线观看 | 一品道一本香蕉视频 | 亚洲欧美日韩中文字幕在线 | 999久久久免费精品国产牛牛 | 一区二区在线欧美日韩中文 | 免费一级毛片在线播放 | 亚洲日本在线播放 | 日韩男女视频 | 国产在线观看入口 | 国产午夜精品久久久久免费视 | 久久久精品2021免费观看 | 国产精品国内免费一区二区三区 | 免费欧洲毛片a级视频老妇女 | 日韩一级片在线 | 国产精品妖精视频 | 奇米影视7777久久精品 | 欧美一级视频在线高清观看 | 一级做性色a爰片久久毛片 一级做性色a爱片久久片 | 久久免费精品 | 日本天堂网在线 | 国产h视频在线观看免费 | 这里精品| 视频一区欧美 | 不卡一级毛片免费高清 | 精品一成人岛国片在线观看 | 啦啦啦免费高清在线影院 |